Cultivated oral mucosal epithelial transplantation for ocular surface reconstruction
نویسندگان
چکیده
منابع مشابه
cultivated limbal and oral mucosal epithelial transplantation
stem cells located at the limbus , are the ultimate source for regeneration of the corneal epithelium in the normal and traumatized states. when limbal stem cells are dysfunctional or deficient, limbal stem cell deficiency (lscd) develops. its surgical management depends on laterality and severity of corneal-limbal involvement. conventional methods of stem cell transplantation are conjunctiva...
متن کاملTransplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders.
BACKGROUND/AIMS To determine outcomes of transplants of cultivated autologous oral epithelial cells in patients with severe ocular surface disorders. METHODS The eyes (n = 6) of four patients with Stevens-Johnson syndrome (three eyes) or chemical burns (three eyes) were studied. Autologous oral epithelial cells, grown for 2-3 weeks on a denuded amniotic membrane carrier in the presence of 3T3...
متن کاملCultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity
PURPOSE To assess the clinical efficacy of cultivated oral mucosal epithelial transplantation (COMET) for the treatment of persistent epithelial defect (PED). METHODS We treated 10 eyes of nine patients with PED (Stevens-Johnson syndrome: three eyes; thermal/chemical injury: five eyes; ocular cicatricial pemphigoid: two eyes) with COMET at Kyoto Prefectural University of Medicine, Kyoto, Japa...
متن کاملCultivated limbal stem cell transplantation for ocular surface reconstruction
Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as vascularized conjunctivalization, keratinization, corneal scarring, and corneal opacification, collectively described as limbal stem cell deficiency (LSCD). Limbal stem cell deficiency may occur as a result of depletion of stem cells or destruction of their stromal niche. In such cases, apart from co...
متن کاملLong-term results of autologous cultivated oral mucosal epithelial transplantation in the scar phase of severe ocular surface disorders.
PURPOSE To investigate the long-term outcome of autologous cultivated oral mucosal epithelial transplantation (COMET) for the treatment of the scar phase of severe ocular surface disorders. Participants This study involved 19 eyes of 17 patients who received autologous COMET for total limbal stem-cell deficiency. METHODS Autologous cultivated oral mucosal epithelial sheets were created using ...
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ژورنال
عنوان ژورنال: Ensho Saisei
سال: 2004
ISSN: 1346-8022,1880-5795
DOI: 10.2492/jsir.24.43